Dudley Benzylation Reagent Trichloroacetimidate Reagents (2-trimethylsilyl)- Ethanesulfonyl Reagents Ethynylnaphthalenes Fluorous Protecting Groups Common Reagents for Protection Common Reagents for Deprotection
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Chemoselective N-Deacetylation of Protected Nucleosides and Nucleotides Promoted by Schwartz's Reagent
Protection and deprotection strategies involving the N-acetyl group are widely utilized in nucleoside and nucleotide chemistry. Herein, we present a mild and selective N-deacetylation methodology, applicable to purine and pyrimidine nucleosides, by means of Schwartz's reagent, compatible with most of the common protecting groups used in nucleoside chemistry.
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Large reserves of coal in Tabas region of Iran are characterized by low ash and high caking index, suitable for use in metallurgy as coking coal. However, these coals cannot be gainfully utilized because of their high sulfur content. In this work, studies on desulfurization of Tabas coals were carried out in a batch reactor using various reagents. The most effective reagents,<...
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Spermidine, spermine and other polyamines 1—5 were selectively protected at the terminal primary amino functions without affecting the secondary amino groups using N-ethoxycarbonylphthalimide (15), the Nefkens’ reagent. Three representative products, 17, 18 and 20, readily underwent acylation at the secondary amino nitrogen to give the corresponding compounds 21—26. Selective deprotection of tw...
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Benzylation of alcohols and other substrates under thermal conditions translates smoothly from conventional heating into MW-assisted organic synthesis (MAOS). Reactions times are decreased from hours to minutes while good to excellent yields are maintained. MW heating should be considered for benzylation of high-value substrates using the title reagent.
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The deprotection step is crucial in order to secure a good quality product in Fmoc solid phase peptide synthesis. 9-Fluorenylmethoxycarbonyl (Fmoc) removal is achieved by a two-step mechanism reaction favored by the use of cyclic secondary amines; however, the efficiency of the reaction could be affected by side reactions and by-product formation. Several aspects have to be taken into considera...
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